Manning studied at Harrow (1822-1827) and at Balliol and Merton College in Oxford where he received his degree as Master of Arts in 1833. In 1832 he was ordained Anglican priest and in December 1832 he was appointed vicar in Lovington, Sussex, and rector in Graffham on 16.09.1833. In November of that year he married Caroline Sargent. In 1837, when he was dean at Midhurst, his wife died after four years of marriage. In 1841 he became archdeacon of Chichester and in 1844 university preacher replacing Newman. He was an active member of the Oxford Movement, just like Newman. In 1848 he had a private audience with pope Pius IX in Rome. On 06.04.1851 he entered the Roman-Catholic church and on 14.06.1851 he was ordained priest by Nicolas Wiseman. He studied in Rome (1851-1854) and received his Doctorate in theology in 1854. Cardinal Wiseman enlisted him in the cathedral chapter of Westminster. From 31.05.1857 until 1865 he was superior of the oblates of St Charles. He was ordained archbishop of Westminster on 30.04.1865 and primate of the Roman Catholic church in England. Pius IX anointed him cardinal in March 1875. Manning was an influential figure in the catholic church and was a confidant of pope Pius IX.