Adolf De Wolf attended the College of Saint Louis, where Guido Gezelle was his English teacher during the school year 1860-1861. He succeeded his unmarried uncle, the bibliophile Louis De Wolf, as a pharmacist in “Den Cleynen Thems” in Bruges, the oldest private pharmacy in Belgium. De Wolf and Gezelle befriended because of their mutual interest in folklore and history. Gezelle wrote occasional poems for the De Wolfs and their children or e.g. to decorate the facade of the pharmacy in honour of the bishop’s inauguration in Bruges. De Wolf was closely involved with the foundation of Gezelle's magazine Biekorf (Beehive): he was one of its first contributors and and its treasurer. The De Wolf family had seven children. Their son Karel followed in his father’s footsteps and also became a pharmacist. Another son, Louis, was appointed chief editor of Biekorf (Beehive).